DePaul University Research Services > Research Protections > Institutional Review Board (IRB) > IRB Protocol Portal
The eProtocol system for the IRB went live on June 1, 2020.
Research Protections section of the Office of Research Services uses
The DePaul eProtocol system for electronic protocol submission and
review. All new initial protocol submissions related to IRB protocols must be submitted using
eProtocol beginning June 1, 2020. The system is web-based and can be
accessible by internet.
At this time, only new protocols, which are being reviewed and approved under the revised regulations which became effective January 21, 2019, can be submitted through the online portal. ORS/IRB will make a decision regarding older protocols on a protocol per protocol basis as to whether it makes sense to re-submit them in the online system. We need to gradually move older protocols into the system so that we are not overloaded.
The best browsers to use for accessing eProtocol are Mozilla Firefox, Safari (version 12 or newer for Mac), and Chrome.
Once logged into eProtocol DO NOT use the 'back button" or “back arrow"
in the browser. If you do so, you will be signed or logged out of the
program and will then need to re-log in. You need to use the navigation
tools within eProtocol to navigate between pages.
Other Important Tips:
To access eProtocol click here: https://researchcompliance.depaul.edu/
To request a person external to DePaul to have access to the eProtocol system (see the FAQ below), complete this form and send to ORP@depaul.edu: Friend of DePaul form -FINAL.pdf
What is eProtocol?
is a web-based Research Administration and compliance software system
for the submission, review and approval process for IBC, IRB, and IACUC
protocols. It will be initiated in phases, with the IBC being the first
board to utilize the system, the IRB being the second board, and the IACUC being the third board.
How do I access and log into eProtocol?
faculty, staff, and students will use their DePaul assigned user ID and
Campus Connect password to log into eProtocol. For example, John Smith
may have been assigned Jsmith22 by DePaul and would have created his own
password to log into Campus Connect. To log in for the first time, you
would click on the link above (https://researchcompliance.depaul.edu/)
and then enter your DePaul user ID and Password in the appropriate
box. You will see a popup that asks you to allow pop ups for this
program. You need to enable pop ups. When you do this, you will be signed
or logged out of the program and will need to log in again. Now, you
should be ready to work. If you utilize more than one computer, you
will need to go through the process of enabling pop ups on each
If you are not a DePaul faculty member, student,
or staff member, but require access to the system, you need to complete a short form (found on the forms and templates page) to obtain a guest/friend of DePaul account. These types of accounts must be renewed annually by ORS. The form allows us to track everyone who has requested and is given this account for the purpose of using the eProtocol system.
How do I learn how to use eProtocol?
will have user guides for Principal Investigators, IRB members, and
ORS staff that should guide you through the protocol submission
process. The ORS staff is also available to assist you with using the
This is a link to a page where the user guides are
posted. The user guides are behind DePaul authentication. This means you
need to have a DePaul user ID and password to have access to these
What if I just want to know the content of the form before actually creating it online in eProtocol?
initiation of the online eProtocol system paper versions of the form
will still be available for a period of time to allow for IRB protocols that remain on paper. Detailed instruction
documents will remain available for the forms on the Forms and Templates
section of the IRB webpage.
Why doesn't my CITI training automatically download into the eProtocol system when I am added to a protocol?